Jun 21, 2016 - Neurologists used spiral drawing analysis for severity evaluation. All the patients were also rated with Fahn-Tolosa-Marin tremor scale (F-T-M.

Abstract Tremor rating scales (TRSs) are used commonly in the clinical assessment of tremor, but the relationship of a TRS to actual tremor amplitude has never been quantified. Consequently, the resolution of these scales is unknown, and the clinical significance of a 1-point change in TRS is uncertain.

We therefore sought to determine the change in tremor amplitude that corresponds to a 1-point change in a typical 5-point TRS. Data from five laboratories were analysed, and 928 patients with various types of hand tremor were studied. Hand tremor was quantified with a graphics tablet in three different labs, an accelerometer in three labs and a mechanical-linkage device in one lab. Tremor in writing, drawing, horizontal posture, rest and finger–nose testing was graded using a variety of TRSs. The relationship between TRS scores and tremor amplitude was computed for each task and laboratory. A logarithmic relationship between a 5-point (0–4) TRS and tremor amplitude ( T, measured in centimetres) was found in all five labs, despite widely varying rating scales and transducer methodology.

Thus, T 2/ T 1 = 10 α(TRS 2−TRS 1). The value of α ranged from 0.414 to 0.441 for writing, 0.355–0.574 for spiral drawing, 0.441 to 0.488 for rest tremor, 0.266–0.577 for postural tremor and 0.306 for finger–nose testing.

For α = 0.3, 0.4, 0.5, 0.6 and 0.7, the ratios T 2/ T 1 for a 1-point decrease in TRS are 0.501, 0.398, 0.316, 0.251 and 0.200. Therefore, a 1-point change in TRS represents a substantial change in tremor amplitude. Knowledge of the relationship between TRS and precise measures of tremor is useful in interpreting the clinical significance of changes in TRS produced by disease or therapy. (1) where T 1 is the initial amplitude of tremor and K is Weber's constant (). Thus, Weber's law states that the smallest discernible change in tremor will be proportional to the initial tremor amplitude. This relationship predicts that any TRS will be a non-linear measure of tremor amplitude.

Autocad 2013 crack 64 bit keygen free. This non-linear relationship is expressed in Fechner's law, which states that a perceived magnitude (i.e. Tremor rating) is proportional to a constant C times the log of stimulus intensity (i.e. Tremor amplitude): TRS = C log T (). This relationship is rewritten in to allow for a non-zero y-intercept. Laboratory Method No.

Laboratory Method No. Laboratory Method No. Laboratory Method No. (6) Assuming a value of α, the ratio of the final value to initial value of tremor amplitude (i.e. T 2/ T 1) and the fractional change in tremor amplitude [i.e. ( T 2− T 1)/ T 1] can be computed for a given change in TRS (i.e.

TRS 2−TRS 1) using. For example, assuming α is 0.5, a 0.5-point reduction in TRS is equivalent to a 43.8% reduction in tremor amplitude [i.e. ( T 2− T 1)/ T 1 = −0.438] and a T 2/ T 1 ratio of 0.562. Similarly, and can be used to compute the change in tremor amplitude for an observed change in TRS.

For example, if α is 0.5, a 50% reduction in tremor amplitude [i.e. ( T 2− T 1)/ T 1 = −0.5] corresponds to a −0.602-point reduction in TRS (). The ratio of final ( T 2) to initial ( T 1) tremor amplitude is plotted versus the change in TRS scores, using the equation shown and values of α equal to 0.1, 0.2, 0.3, 0.4, 0.5, 0.6 and 0.7. Discussion Psychophysics is the scientific study of relationships between physical stimuli and the sensations or perceptions evoked by these stimuli ().